pentobarbital decreases levels of ponatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Steer clear of unless the coadministration outweighs the feasible danger of ponatinib underexposure; monitor for indications of lessened efficacy.
pentobarbital will reduce the level or influence of carvedilol by impacting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Keep an eye on.
Caution with use throughout surgeries or procedures in children young than three yr or in pregnant Females throughout their third trimester
pentobarbital will lessen the level or influence of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.
pentobarbital will minimize the level or outcome of ramelteon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.
pentobarbital will reduce the level or influence of conivaptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will reduce the extent or influence 戊巴比妥鈉製作 of doravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Watch Carefully (2)pentobarbital will lower the level or effect of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Sturdy CYP3A4 inducers may possibly lower suvorexant efficacy; if improved suvorexant dose necessary, usually do not exceed 20 mg/working day
Reserve concomitant prescribing of such medication in sufferers for whom other cure options are inadequate. Limit dosages and durations towards the bare minimum expected. Observe intently for indications of respiratory despair and sedation.
With therapeutic doses of TCAs, barbiturates maximize metabolism and reduce blood concentrations of TCAs.
pentobarbital will decrease the level or effect of alfentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.
pentobarbital will reduce the extent or influence of quinidine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will reduce the level or result of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
pentobarbital will reduce the level or impact of oxybutynin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.